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Does isoniazid change urine color? This medicine commonly causes reddish-orange to reddish-brown discoloration of urine, stool, saliva, sputum, sweat, and tears. Dark urine and yellowing of the eyes or skin (signs of liver problems) are more likely to occur in patients 50 years of age and older.
Why does rifampin cause red urine? Rifampin and Red Urine. Rifampin and its metabolites may color urine, feces, saliva, sputum, sweat, and tears a bright red -orange. This can create a great deal of anxiety for both patients and medical personnel unless they are forewarned of this "harmless" phenomenon.
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