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Is it safe to take prednisone with methotrexate? methotrexate predniSONE Using methotrexate together with predniSONE can increase the blood levels or add to the side effects of methotrexate Talk with your doctor before using these medications together. You may need a dose adjustment or special test if you take both medications.
Does prednisone give you energy? Prednisone can cause an increase in energy. You may also develop insomnia, or difficulty sleeping. Taking the medication in the morning may help to prevent this. 7qwstht2