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The coumadin duration of therapy may be longer in patients with a tissue valve in the mitral location, particularly in the presence of a large left atrium and/or atrial fibrillation . In patients who receive a mechanical heart valve, lifelong anticoagulant therapy is usually needed and low dose aspirin (80 to 100 mg/day) may be added in higher risk coumadin patients . The duration of anticoagulant therapy following tissue heart valve replacement surgery is usually
coumadin 6 to 12 weeks .
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